RTG1 — Candida albicans

Summary

C1_08640W_A (RTG1) in Candida albicans chromosome 1 encodes a basic helix-loop-helix (bHLH) transcription factor with DNA-binding transcription activator activity, protein dimerization activity, and transcription cis-regulatory region binding. It localizes to the nucleus and is associated with positive regulation of transcription by RNA polymerase II, including upregulation of transcription in response to galactose. The gene is linked to alternative respiration, the electron transport chain, mitophagy, and cellular response to reactive oxygen species. It has also been connected to methanol metabolism, galactose breakdown, sphingolipid metabolism and anabolism, and metabolic burst. Additionally, RTG1 is associated with disseminated candidiasis in a mouse model.