OLE1 — Candida albicans

Summary

C1_08360C_A (OLE1, CaOLE1) on Candida albicans chromosome 1 encodes a stearoyl-CoA 9-desaturase (EC 1.14.19.1) with electron transfer activity, iron and heme binding, and domains including acyl-CoA desaturase and cytochrome b5-like heme/steroid-binding regions. This gene is associated with unsaturated fatty acid and lipid A biosynthesis, adiposome formation, mitochondrial inheritance, chlamydospore formation, biofilm formation, filamentous growth in response to neutral pH and starvation, pseudohyphal and hyphal growth, secretion, morphogenesis, hypersensitivity, and responses to heat, starvation, and neutral pH. It localizes to the ER membrane, perinuclear and cortical ER, and the fungal biofilm matrix. Phenotypic associations include abnormal filamentous growth, absent anaerobic growth and hyperosmotic stress resistance, increased alkaline pH resistance, decreased cell death, altered cell cycle progression, and abnormal chitin deposition, septum formation, and protein secretion. Related genes in other species are linked to reduced virulence.