ABCA — Candida albicans

Summary

C1_08070W_A (ABCA, also known as CDR4) in Candida albicans encodes an ATP-binding cassette (ABC) transporter of the PDR/CDR subfamily, possessing NTPase activity and multiple substrate-binding capacities including estradiol, corticosterone, azoles, fluconazole, and phospholipids. The gene is associated with xenobiotic and azole transmembrane transport, response to antibiotics and progesterone, sterol homeostasis, quorum sensing, and inflammatory response. It localizes to the plasma membrane, membrane, and extracellular vesicles. Phenotypic associations link ABCA to abnormal small molecule transport, increased sporulation rate, decreased cell death, and abnormal replicative and chronological lifespan.