EST2 — Candida albicans

Summary

C1_08130C_A (EST2, TERT) in Candida albicans encodes a protein with telomerase reverse transcriptase and telomerase RNA-binding domains. The enzyme possesses telomerase activity, telomerase RNA binding, and telomeric repeat binding functions, and it localizes to the telomerase holoenzyme complex, telomere cap complex, and nucleus. This gene is associated with telomere maintenance via telomerase, telomere capping, DNA strand elongation, homologous recombination, and stem cell renewal. Phenotypic associations include abnormal telomere length, cell cycle progression defects (delayed anaphase, increased metaphase duration, decreased S phase), absent mating-type switching, abnormal spore germination, and altered nuclear size. The gene also links to decreased mitotic recombination, delayed fermentative metabolism, and increased hydrostatic pressure resistance. Studies of related genes in other species connect the family to lifespan regulation and potassium concentration.