COM2 — Candida albicans

Summary

C1_07330W_A (COM2, also known as RME1) in Candida albicans encodes a C2H2-type zinc-finger protein with DNA-binding transcription repressor activity and zinc binding. This gene is associated with negative regulation of filamentous growth, pseudohyphal growth, biofilm formation, phenotypic switching, mating-type switching, chlamydospore formation, and asexual sporulation. It is linked to mitochondrial protein quality control, mycose biosynthesis, aerobic respiration, TOR signaling, oxidative stress response, and cell wall organization. Phenotypic associations include increased thermotolerance, altered cell cycle progression, decreased autophagy, premature meiosis, increased adhesion, increased anaerobic growth, and increased necrotic cell death. Related genes in other species include MSN2.