GPX1 — Candida albicans

Summary

C1_07350C_A (GPX1, also known as GPX3, HYR1, CaHYR1) on Candida albicans chromosome 1 encodes a phospholipid-hydroperoxide glutathione peroxidase with thioredoxin-dependent peroxiredoxin activity (EC 1.11.1.24), containing a thioredoxin-like domain and glutathione peroxidase active-site motifs. The gene is associated with cell redox homeostasis, response to hydrogen peroxide, oxidative stress response, and cellular detoxification of hydrogen peroxide, as well as with lipid oxidation, peptidyl-cysteine oxidation, and ATP anabolism. It is linked to germ tube formation, tube formation, opsonization, T cell polarization, cytokine production, inflammatory response, wound healing, memory, and phagocytosis. Localisation evidence connects the product to mitochondria, cytoplasm, cytosol, and nucleus. Phenotypic associations include increased lifespan, increased vegetative growth, increased viability, decreased hypoosmotic stress resistance, increased acid pH resistance, decreased gamma ray resistance, and altered cell cycle progression, mitochondrial genome maintenance, and redox state.