BRLA — Candida albicans

Summary

C1_07370C_A (BRLA, also known as CPH1) on Candida albicans chromosome 1 encodes a STE12 transcription factor with sequence-specific DNA binding activity. The gene is associated with mating behavior, regulation of pseudohyphal and filamentous growth, parasexual conjugation with cellular fusion, and spindle orientation. It is linked to the anti-inflammatory response, cytokine production, leukocyte adhesion, and response to cyclophosphamide. Associations with biofilm formation, mating efficiency, pheromone production, cell fusion, and carbon source utilization have been observed. The gene product localizes to the nucleus and membrane, and is part of the Tec1p-Ste12p-Dig1p and Ste12p-Dig1p-Dig2p complexes. Related genes in other species are linked to sporogenesis and germination rate.