AMT1 — Candida albicans

Summary

CaAMT1 (C1_07210C_A) on chromosome 1 of Candida albicans encodes an ammonium transporter family protein with ammonium channel activity and methylammonium transmembrane transporter activity. The gene is associated with ammonium import across the plasma membrane, methylammonium membrane transport, and response to iron. It has been connected to regulation of morphogenesis, biofilm formation, flocculation, cell-cell adhesion, TOR signaling, sporulation, pH reduction, ergosterol anabolism, secretion, and protein breakdown. The product localizes to the plasma membrane, fungal-type vacuole, and Golgi complex. Phenotypic associations include abnormal biofilm formation, absent flocculation, increased virulence, increased sporulation, decreased nitrogen source utilization, abnormal pseudohyphal growth, and altered cell cycle progression. Related genes in other species link the ammonium transporter family to nitrogen source utilization.