YPD1 — Candida albicans

Summary

C1_07240W_A (YPD1) in Candida albicans encodes a histidine phosphotransfer kinase that binds histidine kinase and transfers phosphorus-containing groups, placing it at the core of two-component signal transduction. The gene is associated with the histidyl-aspartyl phosphorelay, osmolarity sensing via the two-component system, and activation of the p38 cascade. It is linked to regulation of cellular response to oxidative stress, hyphal growth, mating, cell death, and phagocytosis. Phenotypic associations include decreased hyperosmotic stress resistance, increased pseudohyphal growth, abnormal budding and chromosome segregation, altered cell cycle progression (including G2/M phase transition increase and M phase delay), and changes in respiratory and fermentative metabolism. The protein localises to the cytoplasm, cytosol, and nucleus.