CP1 — Candida albicans

Summary

C1_05770C_A (CP1, also known as PRC3) on Candida albicans chromosome 1 encodes a serine carboxypeptidase (EC 3.4.16.5) belonging to the peptidase S10 family, with serine carboxypeptidase activity. The gene is associated with proteolysis, zymogen activation, digestion, phytochelatin anabolism, cellular response to nitrogen starvation, and protein synthesis. The product localizes to the fungal-type vacuole and its lumen. Phenotypic associations link CP1 to numerous cellular processes, including abnormal autophagy, altered cell death (both increased and decreased), abnormal nuclear fusion during mating, increased aneuploidy, decreased ribophagy and mitophagy, abnormal protein secretion, altered prion inheritance, and changes in lifespan and entry into stationary phase. Studies of related genes in other species connect the family to apoplastic effector function and floral organ identity.