ATG8 — Candida albicans

Summary

C1_05700W_A (ATG8, AUT7) on Candida albicans chromosome 1 encodes a protein belonging to the Atg8-like family with a ubiquitin-like domain, associated with phosphatidylethanolamine binding and protein tagging. This gene is linked to autophagy-related processes including protein targeting to the vacuole involved in autophagy, autophagy of peroxisomes and mitochondria, nucleophagy, ER-phagy, and the cytoplasm-to-vacuole targeting pathway. It is associated with regulation of macroautophagy, membrane invagination, and cellular response to nitrogen starvation. Localization evidence places the product at the PAS, cytoplasmic vesicles, Fungal-type Vacuole Membrane, and Mitochondrial Membrane. The gene is associated with traits including oxidative stress response and phenotypes such as delayed autophagy, decreased lifespan, abnormal filamentous growth, and NUCLEAR IMPORT: DECREASED RATE. Related genes in other species link the family to biomass yield and germination rate.