ACS1 — Candida albicans

Summary

C1_04290C_A (ACS1, also known as ACS2) on Candida albicans chromosome 1 encodes a protein with acetate-CoA ligase and amide synthase activities, and contains AMP-binding and acetyl-CoA ligase domains. The gene is associated with acetyl-CoA metabolism, acetate breakdown, pyruvate fermentation to acetate, the glyoxylate cycle, gluconeogenesis, the carnitine shuttle, fruiting body formation, protein acetylation, CoA metabolism, and response to iron. Phenotypic associations include abnormal carbon source utilization, decreased fermentative metabolism and growth, absent adhesion, altered pheromone production and sensitivity, increased X-ray resistance, and sterility. The gene product localizes to the cytosol, nucleolus, and extracellular space. Studies of related genes in other species link the family to protein content.