PRP5 — Candida albicans

Summary

C1_04520C_A (PRP5, also known as PHO85) in Candida albicans encodes a cyclin-dependent kinase (CDK) with protein serine/threonine kinase activity, classified as EC 2.7.11.22. The gene product exhibits cyclin binding, RNA polymerase II core binding, and histone binding activities. PRP5 is associated with the regulation of cell cycle progression, including decreased rates of overall cell cycle progression and G2 phase progression, alongside increased G1 phase progression. It is linked to reactive oxygen species (ROS) metabolic processes, release of cytochrome c from mitochondria, and cellular responses to glucose starvation. The protein localizes to the CDK holoenzyme, mitotic and meiotic spindles, spindle pole bodies, and the cellular bud neck. Phenotypic associations include altered septum formation, mating efficiency, spore wall formation, and redox state. Studies of related genes in other species link the family to calcium sensitivity, potassium concentration, and oxidative stress response.