LSP1 — Candida albicans

Summary

C1_04680W_A (symbol LSP1, also known as PIL1, CaPIL1, CaPIL2, or CaLSP1) in Candida albicans encodes a member of the PIL1/LSP1 protein family, which contains an AH/BAR domain superfamily fold and is associated with lipid binding. The gene is linked to eisosome assembly, plasma membrane organization, and the localization of adiposomes to the forespore membrane leading edge. It has been associated with hyphal growth, biofilm formation, invasive growth, response to heat and stress, cell cycle control, secretion, and phosphatidylserine and ATP anabolism. Associations with copper sensitivity and numerous phenotypes including abnormal filamentous growth, decreased endocytosis, absent meiosis and cell fusion, altered spore germination, and increased necrotic cell death have been reported. The protein localizes to the eisosome, plasma membrane, nuclear membrane, and prospore membrane structures.