SSA1 — Candida albicans

Summary

SSA1 (SSA2) on Candida albicans chromosome 1 encodes a member of the Hsp70 family of molecular chaperones, possessing ATP hydrolase activity, ATP binding, peptide binding, heat shock protein binding, and protein folding chaperone functions, and also annotated as a transcriptional co-regulator. The gene is associated with numerous biological processes including germ tube formation, tropism, pore formation, fibrinolysis, clotting, wound healing, inflammatory and anti-inflammatory responses, macrophage activation, negative regulation of host defenses, IL-4 production, innate immunity, karyogamy, receptor-mediated endocytosis, peptide transport, and response to cadmium. Phenotypic associations include increased thermotolerance, altered cell cycle progression, increased prion inheritance, premature apoptosis, increased chemical compound accumulation, and decreased colony sectoring. The protein localises to the fungal-type cell wall, plasmalemma, and protein aggregate centre.