HH3 — Candida albicans

Summary

C1_04260W_A (HH3, also known as HHT21 or CSE4) in Candida albicans encodes a histone H3/CENP-A family protein that is a structural constituent of chromatin with nucleosomal DNA binding and protein heterodimerization activity. This gene is associated with kinetochore assembly, centromere localization and separation, mitotic metaphase chromosome alignment, anaphase, and chromosome division. HH3 is associated with delayed cell cycle progression in mid-anaphase and telophase, decreased G2/M phase transition, and premature metaphase-to-anaphase transition. It is linked to increased sporulation and meiosis rates, abnormal mitophagy, decreased hypoosmotic stress resistance, increased gamma ray resistance, altered pheromone-induced cell cycle arrest, and changes in nutrient uptake and vacuolar morphology. The protein localizes to the nucleus, kinetochore, and nucleosome.