ACF2 — Candida albicans

Summary

C1_03680W_A (ACF2, also known as ENG1) in Candida albicans encodes an endo-beta-glucanase with endo-1,3(4)-beta-glucanase and glucan exo-1,3-beta-glucosidase activities, belonging to the GH81 family. The gene is associated with fungal-type cell wall 1,3-beta-glucan metabolism, cell wall polysaccharide breakdown, primary cell septum hydrolysis, and septum digestion after cytokinesis. It is linked to biofilm formation, bipolar cell growth, polar cell growth, ascospore liberation, adhesion of symbiont to host cell, response to host, immune evasion, and IL-1 production. Localization evidence connects the product to the primary cell septum, division septum, cellular bud scar, fungal-type cell wall, and cell cortex. Phenotypic associations include decreased biofilm formation, abnormal filamentous growth, decreased mating efficiency, increased killer toxin resistance, and decreased utilization of carbon and phosphorus sources. Studies of related genes in other species link the family to cytokinesis and stress resistance.