PDR16 — Candida albicans

Summary

C1_03820W_A, also known as PDR16, encodes a protein containing a CRAL-TRIO domain, with annotated phosphatidylcholine intramembrane carrier activity, phosphatidylcholine carrier activity, phosphatidylinositol carrier activity, sterol binding, phosphoinositide binding, and identical protein binding. This Candida albicans gene is associated with intermembrane phospholipid transfer, Golgi vesicle budding, post-Golgi transport, germ tube formation, quorum sensing, nitrogen utilization, and negative regulation of sexual sporulation. It localizes to the Golgi membrane, endosome, cell periphery, fungal biofilm matrix, nucleus-vacuole junction, and adiposome. PDR16 is linked to decreased endocytosis, abnormal Golgi morphology, arrested mitotic cell cycle and G2/M phase transition, decreased meiosis, absent cytokinesis and autophagy, increased exponential phase growth, altered protein secretion and transport, and abnormal endomembrane system morphology. Related genes in other species are linked to phospholipid transport.