EXG1 — Candida albicans

Summary

C1_02990C_A (EXG1/XOG1) on Candida albicans chromosome 1 encodes a protein with endo-(1,6)-beta-D-glucanase activity (EC 3.2.1.58) and glucan exo-1,3-beta-glucosidase activity, also annotated for transferase activity. The product belongs to the glycoside hydrolase family 5. This gene is associated with fungal-type cell wall beta-glucan metabolism, including both glucan breakdown and anabolism, as well as structural organization of the cell wall. EXG1 is linked to host interaction processes such as adhesion of symbiont to host cell, response to host, host invasion, immune evasion, and single-species biofilm formation in or on the host organism. It is associated with phagocytosis, immune response, aerobic respiration, electron transport chain, and sterol metabolism. The protein localizes to the fungal-type cell wall, extracellular vesicles, division septum, and mating projection actin fusion focus. Related genes in other species link the family to carbohydrate content and oxidative stress response.