PST1 — Candida albicans

Summary

C1_03190C_A (PST1, also known as ECM33) in Candida albicans encodes a protein belonging to the CWI-Assembly_Regulator family, which is localized to the cell wall, ascospore wall, and extracellular vesicles. The gene is associated with ascospore wall biogenesis, cell wall organization, plasma membrane organization, biofilm formation, filamentous growth in response to starvation, adhesion of symbiont to host, immune response, phagocytosis, TOR signaling, and response to stress. It has been linked to traits including relative growth rate and numerous phenotypes such as abnormal budding, cytokinesis, and cell cycle progression, increased chitin deposition and flocculation, decreased acquired thermotolerance and mating efficiency, and altered protein transport and endomembrane system morphology. Studies of related genes in other species connect the family to virulence and pathogenicity.