ATG5 — Candida albicans

Summary

C1_02200C_A (ATG5, CaATG5) in Candida albicans chromosome 1 encodes a protein with APG8 ligase activity, cargo receptor ligand activity and enzyme activator activity, and contains ATG5_HBR, Atg5_HR and ATG5_UblA/B domains. The gene is associated with macroautophagy, mitophagy, aggrephagy, ER-phagy, the cytoplasm-to-vacuole targeting (Cvt) pathway, and piecemeal microautophagy of the nucleus (PMN). It is linked to cellular responses to nitrogen and potassium ion starvation, plasma membrane repair, phagocytosis, immune response, host invasion, exocytosis, secretion, protein transport, the apoptotic process, and the meiotic cell cycle. The protein localises to the phagophore assembly site (PAS), phagophore membrane, Atg12-Atg5-Atg16 complex, mitochondria-associated membrane, vacuole-IM contact site, cytosol and nucleus. Phenotypic associations include abnormal pseudohyphal and filamentous growth, absent mitophagy and pexophagy, decreased ribophagy, increased mitochondrial rho- mutation frequency, and altered autophagy, nucleophagy, protein transport and colony size.