SET1 — Candida albicans

Summary

C1_00960C_A (SET1) in Candida albicans encodes a histone H3K4 trimethylase (EC 2.1.1.354) that is a member of the Set1-like family. The gene is associated with chromatin organization, including heterochromatin island assembly, rDNA heterochromatin assembly, telomeric silencing, and silent mating-type cassette chromatin silencing. It is associated with transposable element silencing by heterochromatin formation, regulation of meiotic DNA double-strand break formation, sterol homeostasis, phenotypic switching, ascospore formation, and cellular response to stress. The protein localizes to the nucleus, chromatin, telomeric region, and cytoplasm. Phenotypic associations include altered cell cycle progression through G2/M and G1/S transitions, increased sporulation rate, premature meiosis, abnormal pheromone sensitivity and production, delayed exit from G0, and increased transposable element transposition. Related genes in other species are linked to similar chromatin and cell cycle regulatory processes.