CCH1 — Candida albicans

Summary

CCH1 (C1_01100W_A) in Candida albicans encodes a voltage-gated calcium channel subunit with high voltage-gated calcium channel activity, stretch-activated monoatomic cation-selective calcium channel activity, calcium ion binding, and protein phosphatase regulator activity. The protein localises to the plasma membrane as part of a voltage-gated calcium channel complex. CCH1 is associated with calcium import, calcium signalling, thigmotropism, response to mechanical stimulus, cell polarisation, morphogenesis, hyphal growth, invasive growth, biofilm formation, stress response, hypersensitivity, and ergosterol biosynthesis. It is linked to calcium sensitivity, oxidative stress response, and numerous phenotypes including abnormal cell fusion, absent or decreased budding, abnormal shmoo formation, decreased necrotic cell death, increased alkaline pH resistance, absent filamentous growth, and decreased chitin deposition. Studies of related genes in other species connect the family to acid sensitivity.