UGE1 — Candida albicans

Summary

C1_02150W_A (UGE1, also known as GAL10) on chromosome 1 of Candida albicans encodes a protein with UDP-glucose 4-epimerase, UDP-glucose 4,6-dehydratase, DTDP-glucose 4,6-dehydratase and aldose 1-epimerase activities, belonging to the UDP_G4E and galactose mutarotase-like families. The gene is associated with the Leloir pathway, galactose breakdown and metabolism, UDP-galactose biosynthesis, lactose metabolism, rhamnose anabolism, and nucleotide-sugar metabolism. It is linked to negative regulation of flocculation, downregulation of filamentous growth, invasive growth in response to glucose limitation, cellular response to glucose starvation, fungal-type cell wall biogenesis, and oxidative stress response. Localisation evidence places the product in the cytosol, nucleus and extracellular space. Related genes in other species connect the family to unaffected pathogenicity.