PSD1 — Candida albicans

Summary

C1_00610W_A (PSD1) in Candida albicans encodes a phosphatidylserine decarboxylase (EC 4.1.1.65). The gene is associated with phosphatidylserine, phosphatidylethanolamine, and phosphatidylcholine anabolism, as well as the Kennedy pathway and adiposome formation. It has been linked to mitochondrial inner membrane, nuclear envelope, and ER membrane localization. PSD1 is associated with filamentous growth in response to chemical stimuli, neutral pH, and starvation, along with defense and immune responses, response to cholesterol, and positive regulation of protein processing and mitochondrial fusion. Phenotypic associations include decreased lifespan, abnormal filamentous growth, increased apoptosis rate, decreased budding and meiosis, increased critical cell size at G1, increased ionic stress resistance, and absent protein activity and respiratory metabolism. Studies of related genes in other species link the family to mitochondrial transport and autophagy.