HGC1 — Candida albicans

Summary

C1_00780C_A (HGC1) in Candida albicans chromosome 1 encodes a cyclin-box and cyclin-N domain protein with cyclin-dependent protein serine/threonine kinase regulator activity and protein kinase activity. It is associated with regulation of CDK activity, the G1/S transition of the mitotic cell cycle, cell budding, germ tube formation, tube formation, and positive regulation of filamentous growth, including upregulation in response to pH and quorum sensing. The gene is also linked to cell migration, mating projection assembly, protein unfolding, post-Golgi transport, and traversing the start control point of the mitotic cell cycle. Localisation evidence connects it to the cytoplasm, nucleus, MTOC, and CDK holoenzyme. Studies of related genes in other species link the family to cell cycle control.