TUP1 — Candida albicans

Summary

C1_00060W_A, also known as TUP1 or CaTUP1, encodes a protein with a Tup1 N-terminal domain and WD40 repeats, and is annotated with DNA-binding transcription repressor activity, transcription corepressor activity, mediator complex binding, histone deacetylase binding, histone binding, ubiquitin ligase substrate adaptor function, GTP binding, and phosphatidylinositol (3,5)-bisphosphate binding. TUP1 is associated with regulation of filamentous growth, germ tube formation, filament development, cell migration, tube formation, membrane depolarization, response to farnesol, response to basic pH, response to iron, HOG response, inflammatory response, leukocyte adhesion, mitigation of host defenses by symbiont, negative regulation of isoprenoid metabolism, regulation of chitin and fatty acid anabolism, and negative regulation of dipeptide transport. It localizes to the nucleus, cytoplasm, cytosol, chromatin, transcription repressor complex, Tup11/Tup12 repressor complex, SCF complex, and histone methyltransferase complex. The gene is linked to oxidative stress response and numerous phenotypes including abnormal mating type switching, increased cell cycle progression, altered nutrient uptake, and increased fermentative growth. Studies of related genes in other species connect the family to reduced virulence, salt tolerance, potassium concentration, and acid sensitivity.