PLB1 — Candida albicans

Summary

CR_09690C_A (PLB1, also known as PLB3) in Candida albicans chromosome 8 encodes a lysophospholipase with phospholipase A2 activity, containing a lysoPLipase catalytic domain and an acyltransferase/lysophospholipase domain. The enzyme is associated with host invasion, hyphal growth, germ tube formation, biofilm formation, morphogenesis, and secretion. It has been linked to phosphatidylcholine acyl-chain remodeling, phosphoglycerate catabolism, inflammatory and immune responses, wound healing, phagocytosis, and release of cytochrome c from mitochondria. The protein localizes to the periplasm, plasma membrane, cell wall, extracellular vesicles, endoplasmic reticulum, and cytosol. Phenotypic associations include decreased anaerobic growth, increased alkaline pH resistance, altered endocytosis, abnormal budding, cell cycle arrest, decreased apoptosis, and increased starvation resistance. Studies of related genes in other species link the family to reduced virulence and candidiasis.