INL — Candida albicans

Summary

CR_10100C_A (symbol INL, also known as INO1) in Candida albicans chromosome 8 encodes a myo-inositol-1-phosphate synthase, an enzyme with inositol-3-phosphate synthase activity (EC 5.5.1.4). The gene is associated with inositol anabolism and metabolism, inositol phosphate metabolism, phospholipid anabolism, and phosphate metabolism. It is linked to filament development, morphogenesis, filamentous growth, biofilm formation, mating, steroidogenesis, response to host, and immune evasion. The product localises to the cytoplasm, hyphal cell wall, and cell-bound fractions. Associations with numerous phenotypes include altered cell cycle progression, endocytosis, autophagy-related processes, prion inheritance, chitin deposition, respiratory and fermentative metabolism, and responses to oxidative stress, heat, cold, and X-ray resistance. Studies of related genes in other species link the family to germination rate.