ARF1 — Candida albicans

Summary

CR_08700C_A (ARF1) on Candida albicans chromosome 8 encodes a small GTPase of the Arf1-5-like family with GTPase activity, GTP binding, G protein activity, and protein membrane adaptor function. It is associated with vesicle organization, ER-to-Golgi transport, secretion, protein transport, membrane organization, hyphal growth, invasive growth, morphogenesis, cell growth mode switching from monopolar to bipolar, tubulin assembly, regulation of mitotic cytokinesis, positive regulation of mitotic entry, protein folding, and cellular responses to AOS and xenobiotic stimuli. The gene product localizes to the Golgi membrane, COPII vesicle coat, ER exit site, microtubule cytoskeleton, division septum, cell cortex, and interphase node. Phenotypic associations include absent sporulation and spore germination, decreased cell cycle progression, arrested mitosis, abnormal Golgi morphology, absent chromosome segregation, decreased cell death, increased nutrient uptake, and abnormal endocytosis. Studies of related genes in other species link the family to reduced virulence.