GCN5 — Candida albicans

Summary

CR_06710C_A (GCN5, also known as GCNE, CaNGF-1, CaGCNE, CaGCN5, NGF-1) on Candida albicans chromosome 8 encodes a protein with GNAT and bromodomain motifs, exhibiting histone H3K9, H3K14, H3K18, and H4 acetyltransferase activities as well as histone crotonyltransferase and reader activities for H4K16ac, H4K12ac, and H3K56ac. The gene is associated with regulation of filamentous growth, hyphal growth, biofilm formation, fungal-type cell wall organization, ergosterol and sphingolipid metabolism, secondary metabolism, DNA repair-dependent chromatin remodeling, heterochromatin boundary formation, telomere maintenance, and positive regulation of transcription elongation. It localizes to the nucleus, cytoplasm, chromatin, centromere complex, and the ADA, SALSA, and SWR-C complexes. The gene is linked to disseminated candidiasis in mouse models and to abnormal mitophagy, increased sporulation, altered cell cycle progression, and increased transposable element transposition. Related genes in other species link the family to the SAGA complex and to increased or reduced virulence.