EMI2 — Candida albicans

Summary

CR_07490C_A (EMI2, also known as GLK4, CaGLK1, CaHXK2) on Candida albicans chromosome 8 encodes a hexokinase family protein with hexokinase, glucokinase, fructokinase, mannokinase, N-acetylglucosamine kinase, and glucosamine kinase activities, and binds ATP and D-glucose. It is associated with glycolysis, glucose 6-phosphate metabolism, fructose and mannose metabolism, N-acetylglucosamine and glucosamine breakdown, glycerol anabolism, aerobic respiration, sterol metabolism, cell glucose homeostasis, and fructose uptake. The gene is linked to regulation of phenotypic switching, development of symbiont in host, adhesion of symbiont to host, and the glucose effect. It localizes to mitochondria, cytosol, and nucleus. Associations with disseminated candidiasis in Galleria mellonella and Mus musculus models have been observed. Related genes in other species are linked to oxidative stress response.