EMI2 — Candida albicans

Summary

CR_07150W_A (EMI2, also known as GLK1 or HXK2) on Candida albicans chromosome 8 encodes a hexokinase family protein with hexokinase, glucokinase, fructokinase, mannokinase, N-acetylglucosamine kinase and glucosamine kinase activities, and binds ATP and D-glucose. The gene is associated with glycolysis, glucose 6-phosphate metabolism, mannose and fructose metabolism, glycerol anabolism, aerobic respiration, and sterol metabolism. It is linked to host invasion, adhesion of symbiont to host, development of symbiont in host, regulation of phenotypic switching, and the glucose effect. Localisation evidence connects the product to the cytosol, nucleus and mitochondria. Phenotypic associations include abnormal pheromone production, increased polyploidy, absent budding, decreased critical cell size at G1, delayed chromosome segregation, and altered fermentative and respiratory metabolism. Related genes in other species link the family to oxidative stress response.