ACE2 — Candida albicans

Summary

CR_07440W_A (ACE2) on Candida albicans chromosome 8 encodes a C2H2-type zinc-finger protein with DNA-binding transcription activator activity, RNA polymerase II-specific, and 14-3-3 protein binding capability. The gene is associated with positive regulation of antisense RNA transcription, septum digestion after cytokinesis, and transepithelial migration of the symbiont in the host. It is linked to cell adhesion in single-species biofilm formation, upregulation of filamentous growth in response to chemical stimuli, and regulation of division septum assembly. Additional associations include cellular responses to acidic pH, metal ions, and mechanical stimuli, as well as ergosterol metabolism, calcineurin-mediated signaling, nitrogen utilization, sulfur amino acid metabolism, and regulation of apoptotic processes. The product localizes to chromatin, cytoplasm, cytosol, and nucleus. Studies of related genes in other species link the family to reduced virulence.