OBR1 — Candida albicans

Summary

CR_05380C_A (OBR1, also known as YCP4) on Candida albicans chromosome 8 encodes a flavoprotein of the WrbA-like family with NAD(P)H dehydrogenase (quinone) activity (EC 1.6.5.2) and 2-hydroxy-1,4-benzoquinone reductase activity, binding FMN. The gene is associated with plasma membrane and membrane organization, immune response, stress response, cellular response to oxidative stress, cell cycle modulation, morphogenesis, secretion, and endocytosis. Its product localizes to the eisosome, hyphal cell wall, fungal biofilm matrix, plasma membrane, cytoplasm, cytosol, and nucleus. OBR1 is linked to disseminated candidiasis in a mouse model. Phenotypic associations include abnormal cell cycle progression, increased sporulation, altered freeze-thaw and UV resistance, increased cell death, and decreased chitin deposition. Related genes in other species are linked to oxidative stress response and loss of pathogenicity.