OBR1 — Candida albicans

Summary

CR_05390W_A (OBR1, also known as PST3) in Candida albicans encodes a flavoprotein of the WrbA-like family with NAD(P)H dehydrogenase (quinone) activity (EC 1.6.5.2), specifically 2-hydroxy-1,4-benzoquinone reductase activity, and binds FMN. The gene is associated with response to host, immune response, oxidative stress, hyphal growth, morphogenesis, secretion, endocytosis, cell cycle modulation, and plasma membrane organization. It localizes to the eisosome, hyphal cell wall, fungal biofilm matrix, plasma membrane, cytoplasm, and nucleus. Phenotypic associations include altered cell cycle progression (G1/S, S, metaphase-anaphase, anaphase, telophase), increased sporulation, increased freeze-thaw resistance, altered UV resistance, increased cell death, and increased bipolar budding. Studies of related genes in other species link the family to oxidative stress response and loss of pathogenicity.