GST3 — Candida albicans

Summary

CR_06460W_A (GST3) in Candida albicans chromosome 8 encodes a glutathione S-transferase with glutathione binding and transferase activity, belonging to the GST_C and glutathione S-transferase N-terminal domain families. The gene is associated with glutathione metabolism, cellular detoxification, nitrogen utilization and its regulation, phospholipid transport, IMP anabolism, biofilm formation, hyphal growth, DNA damage response and repair, chromatin modeling, and response to methyl methanesulfonate. The protein localizes to the cytoplasm, cytosol, and nucleus. Phenotypic associations include increased cell cycle progression rate, abnormal mating type switching, increased prion inheritance, decreased hypoosmotic stress resistance, increased nutrient uptake and fermentative growth, absent alkaline pH resistance, decreased adhesion, abnormal colony shape, and increased entry into G0 stationary phase.