PRP5 — Candida albicans

Summary

CR_06050W_A (PRP5, also known as CDC28) on Candida albicans chromosome 8 encodes a cyclin-dependent kinase (CDK) with protein serine/threonine kinase activity, cyclin binding, histone binding, and RNA polymerase II core binding. This gene is associated with regulation of the cell cycle, including upregulation of DNA replication and mitotic cell cycle phase transition, as well as downregulation of mitotic spindle elongation, negative regulation of anaphase-promoting complex-dependent catabolic process, and negative regulation of primary cell septum biogenesis. It is linked to reactive oxygen species metabolic process, release of cytochrome c from mitochondria, cell migration, and regulation of cellular response to glucose starvation. Phenotypic associations include altered cell cycle progression rates, decreased septum formation, increased mating type switching, absent mating efficiency, abnormal lifespan, and decreased redox state. The protein localizes to spindle pole bodies, the mitotic spindle midzone, the cellular bud neck, and the CDK holoenzyme complex.