SAP4 — Candida albicans

Summary

CaSAP4 (CR_05120W_A) on Candida albicans chromosome 8 encodes a SAPS family protein with protein phosphatase binding, activator and regulator activities. It is associated with T cell polarization, anti-inflammatory response, downregulation of kinetochore assembly, IL-1 production, cell motility, inflammatory response, innate immunity, germ tube formation, tube formation, fungal-type cell wall organization or biogenesis, regulation of autophagy, quorum sensing, cellular homeostasis, phagocytosis, localization, protein localisation, immune response, and regulation of signal transduction. The gene product localizes to the nucleus, nucleoplasm, cytosol, chromatin and protein serine/threonine phosphatase complexes. CaSAP4 is linked to cell cycle phenotypes including altered progression through G1/S, G2/M, metaphase and anaphase transitions, abnormal pheromone sensitivity and cell cycle arrest, increased polyploidy, absent budding and adhesion, altered respiratory and fermentative metabolism, and changes in nucleophagy. Related genes in other species such as SAP185, SAP190 and SIT4 connect the family to cell cycle control and phosphatase regulation.