BSC1 — Candida albicans

Summary

CR_04900C_A (BSC1, also known as PGA39) on Candida albicans chromosome 8 encodes the PGA39 protein. This gene is associated with a wide range of biological processes, including biofilm formation, flocculation, cell adhesion, filamentous growth, mating, pheromone response, morphogenesis, signal transduction, response to oxidative stress, fermentation, secretion, and TNF production. It is linked to telomere localization and localizes to the plasma membrane and side of membrane. Phenotypic associations include abnormal or absent biofilm formation and flocculation, increased adhesion and mating efficiency, increased rate of entry into G0, premature G1/S phase transition, delayed cytokinesis, decreased budding rate, increased polyploidy, and absent toxin, osmotic stress, and oxidative stress resistance. Studies of related genes in other species link the family to flocculin and agglutinin-like domains, and to traits such as beta-glucan content and oxidative stress response.