RON1 — Candida albicans

Summary

CR_04250W_A (RON1, also known as NDT80) on Candida albicans chromosome 8 encodes a protein with an NDT80 DNA-binding domain, placing it in the p53-like transcription factor superfamily, and has DNA-binding transcription activator activity. The gene is associated with regulation of carbohydrate utilization, cellular responses to N-acetyl-D-glucosamine and lithium ions, filamentous growth in response to pH and chemical stimuli, germ tube formation, biofilm formation on inanimate substrates, phagocytosis, sexual reproduction, and pheromone response. It localizes to the nucleus and chromatin. Associations with glucose content, sporulation efficiency, spore germination, cell cycle progression through anaphase and metaphase-anaphase transition, meiotic recombination, chromosome segregation, mating type switching, and UV resistance have been recorded. Studies of related genes in other species link the family to meiosis and sporulation.