FEN1 — Candida albicans

Summary

CR_04560C_A (FEN1, also known as RAD27) on Candida albicans chromosome 8 encodes a flap endonuclease with 5'-3' exonuclease activity, a member of the XPG/Rad2 family. This gene is associated with multiple DNA repair pathways including base excision repair, nucleotide excision repair, homologous recombination, non-homologous end joining, and double-strand break repair, as well as Okazaki initiator RNA removal, maintenance of DNA trinucleotide repeats, and gene conversion at the mating-type locus. It is also linked to biofilm formation, sphingolipid anabolism, and cell cycle progression through G1/S and G2 phases. Phenotypic associations include altered X-ray and gamma-ray resistance, abnormal mating response, delayed vegetative growth, premature chromosome segregation, and changes in mutation frequency and mitotic recombination. The protein localizes to the nucleus, nucleolus, nucleoplasm, cytoplasm, cytosol, and mitochondria.