ASPD — Candida albicans

Summary

CR_04570C_A (ASPD, also known as CDC10 or SPN2) on Candida albicans chromosome 8 encodes a septin family protein with a G_SEPTIN domain and P-loop NTPase domain, possessing GTPase activity, GTP binding, phosphatidylinositol-5-phosphate, phosphatidylinositol-4-phosphate, and 1-phosphatidylinositol binding, and acting as a structural constituent of the cytoskeleton. The gene is associated with septin ring assembly and disassembly, cytokinesis, contractile ring assembly, chitin localization, ER polarization, regulation of morphogenesis, quorum sensing, phagocytosis, and protein localization to the bud neck. It localizes to the septin cytoskeleton, septin complex, and mitotic and meiotic septin complexes. Phenotypic associations include abnormal bipolar budding, delayed cytokinesis, absent cell fusion, increased mating efficiency, abnormal filamentous growth, increased hydrostatic pressure resistance, decreased endocytosis, decreased fermentative metabolism, and abnormal colony shape. Related genes in other species link the family to septin function.