HXK1 — Candida albicans

Summary

CR_04510W_A, also known as HXK1 or HXK2 in Candida albicans on chromosome 8, encodes a hexokinase with N-acetylglucosamine kinase, glucosamine kinase, glucokinase, fructokinase and mannokinase activities (EC 2.7.1.1). The protein localises to the cytosol, nucleus and mitochondria. It is associated with canonical glycolysis, glucose 6-phosphate metabolism, fructose and mannose metabolism, glycerol anabolism, cellular respiration, and the regulation of phenotypic switching. The gene is linked to adhesion to and development within the host, cell glucose homeostasis, and N-acetylglucosamine and glucosamine breakdown. Phenotypic associations include abnormal cell cycle progression through G1/S and G2/M phases, increased M phase progression, decreased lifespan, increased anaerobic growth, altered fermentative and respiratory metabolism, and absence of desiccation resistance. Studies of related genes in other species link it to biomass yield and oxidative stress response.