CAM1 — Candida albicans

Summary

CAM1 (RRP9) on Candida albicans chromosome 8 encodes a protein containing WD40 repeats characteristic of the Rrp9-like family and is annotated with U3 snoRNA binding activity. The gene is associated with the nucleolus, SSU processome, and box C/D methylation guide snoRNP complex, and is linked to SSU-rRNA maturation, endonucleolytic cleavage steps in rRNA processing, and cell cycle progression. CAM1 is associated with hyphal growth, germ tube formation, filamentous growth, biofilm formation, flocculation, morphogenesis, and cellular response to xenobiotic stimulus. Associations also include glycogenolysis, threonine anabolism, protein breakdown, meiosis, mitosis, and phenotypes such as altered cell size, increased desiccation resistance, decreased telomere length, increased cold sensitivity, and increased stress resistance. Studies of related genes in other species link the family to 90S preribosome assembly.