ERG25 — Candida albicans

Summary

CR_02370W_A (ERG25, also known as CaERG25 or ERG25B) on Candida albicans chromosome 8 encodes a sterol desaturase-related fatty acid hydroxylase with sphingolipid delta-4 desaturase, sphingolipid C4-monooxygenase, and 4-methylsterol oxidase activities, along with iron binding and redox functions. The gene is associated with ergosterol and sphingolipid biosynthesis, sterol metabolism, MIPC metabolism, PKC signal transduction, quorum sensing, biofilm formation, phenotypic switching, cell adhesion, oxidative phosphorylation, and regulation of gene expression. It is linked to the ER membrane. Loss of ERG25 activity is associated with abnormal plasma membrane morphology, increased cell death and apoptosis, decreased invasive growth and mating efficiency, altered cell cycle progression, reduced nutrient uptake and carbon source utilization, and increased biofilm formation. Related genes in other species connect the family to C-4 methylsterol oxidase function.