ARG4 — Candida albicans

Summary

CR_01330W_A (ARG4, also known as CPA2) on Candida albicans chromosome 8 encodes a carbamoyl-phosphate synthase large subunit, a component of the carbamoyl-phosphate synthase complex. The enzyme possesses carbamoyl-phosphate synthase (ammonia and glutamine-hydrolyzing), aspartate carbamoyltransferase, GMP synthase, and glutaminase activities, and binds ATP, amino acids, and metals. This gene is associated with pyrimidine and arginine biosynthesis, the urea cycle, glutamine metabolism, and de novo UMP biosynthesis. It is linked to biofilm formation, hyphal growth, and homologous recombination. The protein localizes to mitochondria, the cytoplasm, cytosol, and nucleus. Associations with numerous phenotypes include altered replicative lifespan, increased pseudohyphal growth, increased osmotic stress resistance, decreased gamma ray resistance, increased apoptosis, and changes in nutrient uptake, respiratory metabolism, and mitochondrial genome maintenance.