SEF1 — Candida albicans

Summary

CR_02190C_A (SEF1, CaSEF1) on Candida albicans chromosome 8 encodes a Zn2Cys6 DNA-binding transcription activator. The gene is associated with regulation of cellular response to iron ion starvation, riboflavin transport and anabolism, fatty acid oxidation, protein lipoylation, response to host, innate immunity, immune evasion, quorum sensing, phagocytosis, ER stress response, glucose metabolism, pentose-phosphate shunt, iron-sulfur cluster assembly, and cellular response to basic pH. SEF1 localises to both cytoplasm and nucleus. Phenotypic associations include increased filamentous growth, decreased viability, abnormal colony appearance, decreased anaerobic growth, increased killer toxin resistance, absent invasive growth, decreased ribophagy, increased mitochondrial rho- mutation frequency, abnormal meiosis, increased lifespan, abnormal sporulation, decreased hydrostatic pressure resistance, and abnormal cell cycle progression. The gene has also been linked to disseminated candidiasis in a mouse model.