MET6 — Candida albicans

Summary

CR_01620C_A (MET6) on Candida albicans chromosome 8 encodes a cobalamin-independent methionine synthase (EC 2.1.1.14) with zinc-binding activity, belonging to the Cbl-indep_Met_Synth_N and Met_Synth_C/arc domain families. The gene is associated with methionine, sulfur amino acid, ergosterol, sterol, adenine, and GMP metabolism, as well as mRNA breakdown, regeneration, antibody production, immune response, cell-cell adhesion, host invasion, and perturbation of host immune response. Its product localizes to the cytosol, nucleus, hyphal cell wall, fungal-type cell wall, and fungal biofilm matrix. Phenotypic associations include altered prion inheritance, increased replicative and chronological lifespan, decreased thermotolerance and stress resistance, increased oxidative stress resistance, decreased fermentative and respiratory growth, decreased acid pH and hydrostatic pressure resistance, abnormal liquid culture appearance, auxotrophy, and altered nitrogen source utilization. Studies of related genes in other species link the family to haploproficiency.