CLR3 — Candida albicans

Summary

CR_02050C_A (CLR3, also known as HDA1) on Candida albicans chromosome 8 encodes a protein with histone deacetylase activity, including histone H3-K9, H3-K14, H4-K5, H4-K8, H4-K12 and H4-K16 deacetylase activities, and is annotated as EC 3.5.1.98. The gene is associated with epigenetic regulation of gene expression, chromatin silencing, heterochromatin island and rDNA heterochromatin assembly, centromeric silencing, and nucleosome disassembly. It is linked to the regulation of phenotypic switching, filamentous growth in response to pH and starvation, TOR signaling, and cell fate specification and determination. Phenotypic associations include increased mating-type switching, abnormal pheromone production, increased sporulation rate, increased fermentative growth, increased anaerobic growth, increased freeze-thaw resistance, and absent desiccation resistance. The protein localises to the HDA1 complex, HDAC complex, euchromatin, and subtelomeric heterochromatin.